1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

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Chemical Name:1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one
CAS No.:280120-61-8
Molecular Formula:C₂₀H₁₇BrN₄O₃
Molecular Weight:441.284
Hs Code.:

Synonyms:1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

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Chemical Property of 1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

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Technology Process of 1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

There total 11 articles about 1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 280120-62-9
6-(4-bromo-phenyl)-1-(4-methoxy-phenyl)-5-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid

: 280120-61-8
1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

Guidance literature:: 6-(4-bromo-phenyl)-1-(4-methoxy-phenyl)-5-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃;

With sodium tetrahydroborate; In methanol;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: 280120-60-7
1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

: 543-27-1
isobutyl chloroformate

: 280120-61-8
1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

Guidance literature:: With 4-methyl-morpholine; hydrogenchloride; potassium hydroxide; sodium borohydrid; In tetrahydrofuran; methanol; water;

Reference yield:

: 280119-61-1
3-Ethyl-5-methyl (1-[4-Methoxyphenyl]-4-amino)pyrazole-3,5-dicarboxylate

: 280120-61-8
1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaNO₂; TFA / 0 °C

1.2: 90 percent / NaN₃

2.1: 75 percent / aq. LiOH / tetrahydrofuran

3.1: (COCl)2 / CH₂Cl₂

4.1: CH₂Cl₂

5.1: SnCl₂*2H₂O / methanol / 65 °C

6.1: Heating

7.1: 85 percent / aq. KOH / methanol; tetrahydrofuran

8.1: isobutyl chloroformate; NMM / tetrahydrofuran / 0 °C

8.2: 75 percent / NaBH₄ / methanol

With 4-methyl-morpholine; potassium hydroxide; lithium hydroxide; oxalyl dichloride; trifluoroacetic acid; tin(ll) chloride; sodium nitrite; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.044