1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

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Chemical Name:1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one
CAS No.:280120-60-7
Molecular Formula:C₂₂H₁₉BrN₄O₄
Molecular Weight:483.321
Hs Code.:

Synonyms:1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

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Chemical Property of 1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

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Technology Process of 1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

There total 10 articles about 1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 280119-64-4
1-[4-methoxyphenyl]-3-(ethoxycarbonyl)-4-azido-5-[4-bromophenylaminocarbonyl]pyrazole

: tin(II)chloride dihydrate

: 280120-60-7
1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

Guidance literature:: In N,N-dimethylacetamide dimethyl acetal; ethanol; acetic acid; ethyl acetate;

Reference yield:

: 280119-61-1
3-Ethyl-5-methyl (1-[4-Methoxyphenyl]-4-amino)pyrazole-3,5-dicarboxylate

: 280120-60-7
1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaNO₂; TFA / 0 °C

1.2: 90 percent / NaN₃

2.1: 75 percent / aq. LiOH / tetrahydrofuran

3.1: (COCl)2 / CH₂Cl₂

4.1: CH₂Cl₂

5.1: SnCl₂*2H₂O / methanol / 65 °C

6.1: Heating

With lithium hydroxide; oxalyl dichloride; trifluoroacetic acid; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: 4-azido-5-chlorocarbonyl-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 280120-60-7
1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂

2: SnCl₂*2H₂O / methanol / 65 °C

3: Heating

With tin(ll) chloride; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.044