(S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide

Base Information

Chemical Name:(S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide
CAS No.:340166-83-8
Molecular Formula:C₂₀H₃₂N₄O₂
Molecular Weight:360.5
Hs Code.:

Synonyms:(S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide

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Chemical Property of (S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide

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Technology Process of (S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide

There total 6 articles about (S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 7693-46-1
4-Nitrophenyl chloroformate

: 207121-91-3
(S)-N-benzyl 2-amino-3,3-dimethylbutanamide

: 340166-83-8
(S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide

Guidance literature:: 4-Nitrophenyl chloroformate; (S)-N-benzyl 2-amino-3,3-dimethylbutanamide; With pyridine; In dichloromethane; for 0.166667h;

(1R,2R)-1,2-diaminocyclohexane; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h; Further stages.;
DOI:10.1021/ja027246j

Reference yield:

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: ((S)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

: 340166-83-8
(S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1002/1615-4169(20010226)343:2<197::AID-ADSC197>3.0.CO;2-8

Reference yield:

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 340166-83-8
(S)-2-[3-((1R,2R)-2-Amino-cyclohexyl)-ureido]-N-benzyl-3,3-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: HBTU; iPr₂NEt / CH₂Cl₂ / 1.5 h / 20 °C

2: CF₃COOH / CH₂Cl₂ / 1 h / 20 °C

3: pyridine / CH₂Cl₂ / 0.17 h / 20 °C

4: 6.25 g / iPr₂NEt / CH₂Cl₂ / 0.17 h / 20 °C

With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/1615-4169(20010226)343:2<197::AID-ADSC197>3.0.CO;2-8