(3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

Base Information

Chemical Name:(3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one
CAS No.:442631-47-2
Molecular Formula:C₄₀H₅₆O₃S₂Si
Molecular Weight:677.1
Hs Code.:

(3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

Synonyms:(3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

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Chemical Property of (3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

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Technology Process of (3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

There total 6 articles about (3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 442631-46-1
Carbonic acid benzyl ester (3S,8R,9S,10R,13S,14S,17S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-16-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

: 442631-47-2
(3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

Guidance literature:: With methanol; sodium methylate; for 2h; Heating;
DOI:10.1021/ja012119t

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 442631-47-2
(3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / Et₃N / CH₂Cl₂ / 12 h / 25 °C

2.1: 73 percent / H₂NNH₂*H₂O / tetrahydrofuran; methanol / 8 h / Heating

3.1: 96 percent / Dess-Martin periodinane

4.2: HMPA / 2 h / 25 °C

4.3: 63 percent / 0.08 h / -78 °C

5.1: 99 percent / NaOMe; MeOH / 2 h / Heating

With methanol; sodium methylate; Dess-Martin periodane; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja012119t

Reference yield:

: 285554-48-5
3β-{[tert-butyl(dimethyl)silyl]oxy}-16α,17α-epoxypregn-5-en-20-one

: 442631-47-2
(3S,8R,9S,10R,13S,14S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-hydroxy-10,13-dimethyl-17-(1-methyl-2,2-bis-phenylsulfanyl-ethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 73 percent / H₂NNH₂*H₂O / tetrahydrofuran; methanol / 8 h / Heating

2.1: 96 percent / Dess-Martin periodinane

3.2: HMPA / 2 h / 25 °C

3.3: 63 percent / 0.08 h / -78 °C

4.1: 99 percent / NaOMe; MeOH / 2 h / Heating

With methanol; sodium methylate; Dess-Martin periodane; hydrazine hydrate; In tetrahydrofuran; methanol;
DOI:10.1021/ja012119t