methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

Base Information

Chemical Name:methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate
CAS No.:1448893-61-5
Molecular Formula:C₂₀H₁₆ClF₃N₄O₃
Molecular Weight:452.82
Hs Code.:

Synonyms:methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

Suppliers and Price of methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

There total 4 articles about methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1448594-73-7
2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride

: 87600-71-3
4,6-dichloro-5-pyrimidinecarboxylic acid methyl ester

: 1448893-61-5
methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

Guidance literature:: 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

4,6-dichloro-5-pyrimidinecarboxylic acid methyl ester; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 1448545-44-5
2-(2-fluoro-4-hydroxyphenyl)ethylamine-tert-butyl carbamate

: 1448893-61-5
methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

1.2: 6 h / 160 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 80 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 52133-37-6
C₈H₁₀FNO

: 1448893-61-5
methyl 4-chloro-6-[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.5 h / 20 °C

2.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

2.2: 6 h / 160 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 80 °C

With hydrogenchloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;