ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate

Base Information

• Chemical Name: ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate
• CAS No.: 156759-26-1
• Molecular Formula: C₁₉H₂₇NO₄
• Molecular Weight: 333.428
• Mol file: 156759-26-1.mol

Synonyms:ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate

Chemical Property of ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate

There total 4 articles about ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methylcyclohexanone (583-60-8) → ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate (156759-26-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 62.3 percent / p-TsOH / benzene / Heating; azeotropic dist.

2: 2) H₂O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h

3: 31.1 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 °C

4: 1) NaH / 1) DMF, 1 h, RT, 2) DMF, 150 deg C, 5 h

With water; hydrogen bromide; acetic anhydride; sodium hydride; toluene-4-sulfonic acid; In benzene;

DOI:10.1002/hlca.19940770507

Reference yield:

6-methyl-1-pyrrolidino-1-cyclohexene (5049-51-4) → ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate (156759-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 2) H₂O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h

2: 31.1 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 °C

3: 1) NaH / 1) DMF, 1 h, RT, 2) DMF, 150 deg C, 5 h

With water; hydrogen bromide; acetic anhydride; sodium hydride;

DOI:10.1002/hlca.19940770507

Reference yield:

2-(4-methoxybenzyl)-6-methylcyclohexan-1-one (158096-70-9) → ethyl N-(2-<4-(3-methyl-2-oxocyclohex-1-ylmethyl)phenoxy>ethyl)carbamate (156759-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 31.1 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 °C

2: 1) NaH / 1) DMF, 1 h, RT, 2) DMF, 150 deg C, 5 h

With hydrogen bromide; acetic anhydride; sodium hydride;

DOI:10.1002/hlca.19940770507

upstream raw materials:

ethyl N-(2-chloroethyl)carbamate

2-(4-hydroxybenzyl)-6-methylcyclohexan-1-one

6-methyl-1-pyrrolidino-1-cyclohexene

2-Methylcyclohexanone