methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

Base Information

Chemical Name:methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate
CAS No.:1428533-36-1
Molecular Formula:C₂₅H₂₇ClN₄O₄
Molecular Weight:482.967
Hs Code.:

Synonyms:methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

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Chemical Property of methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

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Technology Process of methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

There total 4 articles about methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1118-12-3
1,1-dimethylethylurea

: 1428533-21-4
methyl 2-(6-benzyl-3,5-dichloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

: 1428533-36-1
methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; at 100 ℃; for 0.25h; chemoselective reaction; Microwave irradiation;
DOI:10.1021/jm301887f

Reference yield:

: 15028-40-7,13226-98-7
DL-2-phenylglycine methyl ester hydrochloride

: 1428533-36-1
methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 0.02 h / 20 °C

1.2: 0.5 h / Reflux

2.1: hydrogenchloride / diethyl ether / 0.08 h

2.2: Reflux

3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; diethyl ether; 1.1: |Strecker Aminoacid Synthesis / 1.2: |Strecker Aminoacid Synthesis;
DOI:10.1021/jm301887f

Reference yield:

: C₁₈H₁₈N₂O₂

: 1428533-36-1
methyl 2-(6-benzyl-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / diethyl ether / 0.08 h

1.2: Reflux

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; diethyl ether;
DOI:10.1021/jm301887f