Technology Process of (E)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)-3-phenylprop-2-en-1-one
There total 7 articles about (E)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)-3-phenylprop-2-en-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone;
With
sodium hydroxide;
In
ethanol; water;
for 0.0833333h;
benzaldehyde;
In
ethanol; water;
at 20 ℃;
for 24h;
DOI:10.1016/j.bmcl.2012.12.094
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 12 h / Reflux
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: hydrazine hydrate / 0.5 h / 20 °C
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
5.1: boron trifluoride diethyl etherate / dichloromethane / 24 h / 20 °C / Inert atmosphere; Cooling with ice
6.1: sodium hydroxide / ethanol; water / 0.08 h
6.2: 24 h / 20 °C
With
boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; hydrazine hydrate; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
5.1: |Friedel-Crafts Acylation / 6.1: |Claisen-Schmidt Condensation / 6.2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2012.12.094
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride / diethyl ether / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate / acetone / 12 h / Reflux
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
3.2: 1 h / Inert atmosphere
4.1: hydrazine hydrate / 0.5 h / 20 °C
5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
6.1: boron trifluoride diethyl etherate / dichloromethane / 24 h / 20 °C / Inert atmosphere; Cooling with ice
7.1: sodium hydroxide / ethanol; water / 0.08 h
7.2: 24 h / 20 °C
With
aluminum (III) chloride; boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; hydrazine hydrate; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
1.1: |Friedel-Crafts Acylation / 6.1: |Friedel-Crafts Acylation / 7.1: |Claisen-Schmidt Condensation / 7.2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2012.12.094
![1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone](/Databaselist/images/loading.webp)
