N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide

Base Information

Chemical Name:N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide
CAS No.:509093-93-0
Molecular Formula:C₂₇H₃₃N₅O₄
Molecular Weight:491.59
Hs Code.:

Synonyms:N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide

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Chemical Property of N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide

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Technology Process of N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide

There total 9 articles about N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: C₂₉H₃₅N₅O₅

: 509093-93-0
N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2015.10.060

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 509093-93-0
N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

2: N-ethyl-N,N-diisopropylamine / 110 °C

3: tin(II) chloride dihdyrate / ethanol; ethyl acetate / 100 °C

4: acetonitrile; methanol; water / 100 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide

6: diisobutylaluminium hydride / toluene; tetrahydrofuran

With 4-methyl-morpholine; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2015.10.060