benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate

Base Information

Chemical Name:benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate
CAS No.:945534-39-4
Molecular Formula:C₄₈H₄₉N₅O₅
Molecular Weight:775.948
Hs Code.:

Synonyms:benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate

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Chemical Property of benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate

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Technology Process of benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate

There total 5 articles about benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₇N₅O₄

: 606-83-7
3,3-Diphenylpropionic acid

: 945534-39-4
benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm070246f

Reference yield:

: 945534-33-8
Boc-2'-formyl-D-tryptophan

: 945534-39-4
benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-methyl-morpholine; MgSO₄; NaCNBH₃ / CH₂Cl₂ / 2 h / pH 6

2: pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / acetonitrile; H₂O / 0 - 20 °C

3: aq. TFA / acetonitrile / 1 h / 20 °C

4: NEt₃; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; pyridine; sodium cyanoborohydride; magnesium sulfate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm070246f

Reference yield:

: 1026316-05-1
C₃₈H₄₇N₅O₇

: 945534-39-4
benzyl (5R)-6-(benzylamino)-5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-oxohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / acetonitrile; H₂O / 0 - 20 °C

2: aq. TFA / acetonitrile / 1 h / 20 °C

3: NEt₃; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm070246f