2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

Base Information

Chemical Name:2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester
CAS No.:245062-21-9
Molecular Formula:C₃₉H₄₈N₆O₄
Molecular Weight:664.848
Hs Code.:

2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

Synonyms:2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

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Chemical Property of 2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

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Technology Process of 2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

There total 6 articles about 2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179026-35-8
1-(4-cyanophenylmethyl)-1H-imidazol-5-ylacetic acid

: (S)-2-{2-[((2S,3S)-2-Amino-3-methyl-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methyl-pentanoic acid methyl ester; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 245062-21-9
2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm990080l

Reference yield:

: 3251-69-2
2-(1H-imidazol-5-yl)acetic acid hydrochloride

: 245062-21-9
2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / HCl / 18 h / 20 °C

2: 75 percent / Et₃N / dimethylformamide / 72 h

3: acetonitrile / 18 h / 55 °C

4: MeOH / 0.5 h / Heating

5: 1 M aq. LiOH / tetrahydrofuran / 16 h / 20 °C

6: HOOBT; EDC; Et₃N / dimethylformamide / 20 °C

With hydrogenchloride; methanol; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: Esterification / 2: Alkylation / 3: quaternization / 4: methanolysis / 5: Hydrolysis / 6: amidation;
DOI:10.1021/jm990080l

Reference yield:

: 145133-11-5
methyl [1-(triphenylmethyl)-1H-imidazol-4-yl]acetate

: 245062-21-9
2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 18 h / 55 °C

2: MeOH / 0.5 h / Heating

3: 1 M aq. LiOH / tetrahydrofuran / 16 h / 20 °C

4: HOOBT; EDC; Et₃N / dimethylformamide / 20 °C

With methanol; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: quaternization / 2: methanolysis / 3: Hydrolysis / 4: amidation;
DOI:10.1021/jm990080l