145133-11-5

Basic information

• Product Name: methyl (1-trityl-1H-imidazol-4-yl)acetate
• Synonyms: 1H-imidazole-4-acetic acid, 1-(triphenylmethyl)-, methyl ester; Methyl (1-trityl-1H-imidazol-4-yl)acetate
• CAS NO: 145133-11-5
• Molecular Formula: C₂₅H₂₂N₂O₂
• Molecular Weight: 382.4544
• Mol File: 145133-11-5.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 518.668°C at 760 mmHg
• Flash Point: 267.481°C
• Density: 1.11g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: methyl (1-trityl-1H-imidazol-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (1-trityl-1H-imidazol-4-yl)acetate(145133-11-5)
• EPA Substance Registry System: methyl (1-trityl-1H-imidazol-4-yl)acetate(145133-11-5)

Safety Data

• Hazardous Substances Data: 145133-11-5(Hazardous Substances Data)

Upstream product

• 596-43-0 bromo-triphenyl-methane 
• 51718-80-0 methyl 2-(1H-imidazol-4-yl)acetate hydrochloride 
• 76-83-5 trityl chloride 
• 3251-69-2 imidazole-4-acetic acid hydrochloride 
• 3251-69-2 2-(1H-imidazol-5-yl)acetic acid hydrochloride 
• 4200-46-8 (1H-imidazol-4-yl)-acetic acid methyl ester 

Downstream Products

• 199007-39-1 (±)-methyl 3-phenyl-2-(1-trityl-1H-imidazol-4-yl)propanoate 
• 179025-89-9 1-(4-nitrophenylmethyl)-1H-imidazol-5-ylacetic acid methyl ester 
• 445434-57-1 methyl [1-(4-Cyano-3-fluorobenzyl)-1H-imidazol-5-yl]acetate 
• 179026-34-7 [1-(4-Cyanobenzyl)-1H-imidazol-5-yl]acetic acid methyl ester 
• 179026-41-6 1-(Phenylmethyl)-1H-imidazol-5-ylacetic acid methyl ester 
• 179026-12-1 2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-(methylsulfanyl)butyric acid methyl ester 
• 245062-21-9 2(S)-<2-[(2(S)-<2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-methylpentanoic acid methyl ester 
• 179026-32-5 2(S)-<2-[(2(S)-<2-[3-(4-fluorobenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-(methylsulfanyl)butyric acid methyl ester 
• 179026-14-3 2(S)-<2-[(2(S)-<2-[3-(4-methoxybenzyl)-3H-imidazol-4-yl]acetylamino>-3(S)-methylpentyl)naphthalen-1-ylmethylamino]acetylamino>-4-(methylsulfanyl)butyric acid methyl ester 

Relevant articles and documents

ACYCLIC CXCR4 INHIBITORS AND USES THEREOF

The present invention relates to compounds and methods useful for modulation, e.g. inhibition, of C-X-C receptor type 4 (CXCR4). The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using the compositions in the treatment of various disorders.

Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone

The ρ-containing γ-aminobutyric acid type A receptors (GABAARs) play an important role in controlling visual signaling. Therefore, ligands that selectively target these GABAARs are of interest. In this study, we demonstrate that the partial GABAAR agonist imidazole-4-acetic acid (IAA) is able to penetrate the blood–brain barrier in vivo; we prepared a series of α- and N-alkylated, as well as bicyclic analogues of IAA to explore the structure–activity relationship of this scaffold focusing on the acetic acid side chain of IAA. The compounds were prepared via IAA from l-histidine by an efficient minimal-step synthesis, and their pharmacological properties were characterized at native rat GABAARs in a [3H]muscimol binding assay and at recombinant human α1β2γ2Sand ρ1GABAARs using the FLIPR membrane potential assay. The (+)-α-methyl- and α-cyclopropyl-substituted IAA analogues ((+)-6 a and 6 c, respectively) were identified as fairly potent antagonists of the ρ1GABAAR that also displayed significant selectivity for this receptor over the α1β2γ2SGABAAR. Both 6 a and 6 c were shown to inhibit GABA-induced relaxation of retinal arterioles from porcine eyes.

Prenyl transferase inhibitors

A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R23); and the remaining substituents are as defined in the disclosure.