2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

Base Information

Chemical Name:2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid
CAS No.:1314863-84-7
Molecular Formula:C₂₂H₂₂N₂O₄
Molecular Weight:378.428
Hs Code.:

Synonyms:2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

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Chemical Property of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

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Technology Process of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

There total 7 articles about 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 1314863-90-5
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyrrolactone

: 1314863-84-7
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

Guidance literature:: With water; sodium hydroxide; In methanol; for 3h; Reflux;
DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

: 1314863-87-0
2,2-diphenyl-3-benzyloxy propionitrile

: 1314863-84-7
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / toluene / 0 - 20 °C / Inert atmosphere

2.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / acetic acid / 22 h / 100 - 110 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

4.2: 5 h / 90 °C

5.1: water; sodium hydroxide / methanol / 3 h / Reflux

With sulfuric acid; water; diisobutylaluminium hydride; potassium carbonate; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

: 1314863-88-1
2,2-diphenyl-3-benzyloxy propylaldehyde

: 1314863-84-7
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

1.2: 20 °C

2.1: sulfuric acid / acetic acid / 22 h / 100 - 110 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

3.2: 5 h / 90 °C

4.1: water; sodium hydroxide / methanol / 3 h / Reflux

With sulfuric acid; water; potassium carbonate; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.034