methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Base Information

Chemical Name:methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate
CAS No.:1393593-37-7
Molecular Formula:C₂₁H₂₈N₂O₂
Molecular Weight:340.466
Hs Code.:

Synonyms:methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

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Chemical Property of methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Chemical Property:

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Technology Process of methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

There total 3 articles about methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1393593-36-6
methyl (3S, αR)-3-[N-( 3'-azidopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: 1393593-37-7
methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Guidance literature:: methyl (3S, αR)-3-[N-( 3'-azidopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.5h;

With water; In tetrahydrofuran; at 50 ℃; for 2h;
DOI:10.1021/jo3012732

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1393593-37-7
methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

3.1: sodium azide; sodium iodide / dimethyl sulfoxide / 24 h / 50 °C

4.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C

4.2: 2 h / 50 °C

With n-butyllithium; sodium azide; triphenylphosphine; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo3012732

Reference yield:

: 1393593-35-5
methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: 1393593-37-7
methyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide; sodium iodide / dimethyl sulfoxide / 24 h / 50 °C

2.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C

2.2: 2 h / 50 °C

With sodium azide; triphenylphosphine; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jo3012732