(+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate

Base Information

Chemical Name:(+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate
CAS No.:130506-56-8
Molecular Formula:C₂₇H₃₄O₄
Molecular Weight:422.565
Hs Code.:

Synonyms:(+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate

Chemical Property:

Purity/Quality:

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Technology Process of (+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate

There total 27 articles about (+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 130506-55-7
(8R,9S,10R,13S,14S,17S)-17-((S)-1,2-Dihydroxy-ethyl)-13-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

: 98-88-4
benzoyl chloride

: 130506-56-8
Benzoic acid (S)-2-hydroxy-2-((8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl ester

Guidance literature:: With pyridine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1039/c39900001001

Reference yield: 52.0%

: 98-88-4
benzoyl chloride

: 130506-55-7
(+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-3-one

: 130506-56-8
(+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate

Guidance literature:: With pyridine; dmap; In dichloromethane; for 1h;

Reference yield:

: 135502-12-4
(+)-(2E,4S)-4,5-isopropylidenedioxy-2-methylpent-2-enyl acetate

: 130506-56-8
(+)-(20S)-20,21-dihydroxy-19-norpregn-4-en-5-one 21-benzoate

Guidance literature:: Multi-step reaction with 13 steps

2: lithium aluminium hydride / tetrahydrofuran / 5 h / 0 °C

3: 87 percent / pyridine / 3 h / 0 °C

4: 99 percent / sodium iodide / acetone / 47 h

5: 1) sodamide / 1) THF, -33 deg C, 30 min, 2) THF, -33 deg C, 1 h

6: sodium, ethanol / 0.5 h / -78 °C

7: 98 percent / 1,2-dichloro-benzene / 13 h / Heating

8: 75 percent / lithium metal, liq. ammonia, EtOH / tetrahydrofuran / 0.75 h / -78 °C

9: 94 percent / d-camphor-10-sulphonic acid / CH₂Cl₂ / 1 h / Ambient temperature

10: 1) lithium, liq. NH₃ / 1) THF, -78 deg C, 30 min, 2) -78 deg C, 30 min

11: 73 percent / mercury(II)trifluoroacetate / nitromethane / 3 h

12: 81 percent / 10percent aq. KOH / methanol / 2 h

13: 52 percent / pyridine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h

With pyridine; dmap; potassium hydroxide; lithium aluminium tetrahydride; ethanol; camphor-10-sulfonic acid; ammonia; mercury(II) trifluoroacetate; sodium; lithium; sodium amide; sodium iodide; In tetrahydrofuran; methanol; nitromethane; dichloromethane; 1,2-dichloro-benzene; acetone;