(5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol

Base Information

Chemical Name:(5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol
CAS No.:1620893-63-1
Molecular Formula:C₂₂H₂₆N₂O₅
Molecular Weight:398.459
Hs Code.:

Synonyms:(5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol

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Technology Process of (5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol

There total 4 articles about (5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1620893-61-9
5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazole-4-carbaldehyde

: 89980-69-8
3,4-dimethoxyphenylmagnesium bromide

: 1620893-63-1
(5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol

Guidance literature:: In tetrahydrofuran; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.016

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1620893-63-1
(5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

1.2: 24 h / 25 °C / Inert atmosphere

2.1: triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere

3.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

3.2: 12 h / 25 °C / Inert atmosphere

4.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

With triethylsilane; boron trifluoride diethyl etherate; ethylmagnesium bromide; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2014.06.016

Reference yield:

: 1415582-64-7
(3,4-dimethoxyphenyl)(4-iodo-1-methyl-1H-imidazol-5-yl)methanol

: 1620893-63-1
(5-(3,4-dimethoxybenzyl)-1-methyl-1H-imidazol-4-yl)(3,4-dimethoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

3.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

With triethylsilane; boron trifluoride diethyl etherate; ethylmagnesium bromide; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2014.06.016