4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide
• CAS No.: 1620066-67-2
• Molecular Formula: C₁₈H₁₈N₂O₃S
• Molecular Weight: 342.419
• Mol file: 1620066-67-2.mol

Synonyms:4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide

Chemical Property of 4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide

There total 4 articles about 4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-methylindole (603-76-9) + 4-phenoxy-1-tosyl-1H-1,2,3-triazole (1620066-64-9) → 4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide (1620066-67-2)

Guidance literature:

1-methylindole; 4-phenoxy-1-tosyl-1H-1,2,3-triazole; In 1,2-dichloro-ethane; at 80 ℃; for 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;

With amberlyst 15; In water; 1,2-dichloro-ethane; at 50 ℃; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/ja5058967

Reference yield: 83.0%

1-methylindole (603-76-9) + 4-ethyloxy-1-(4-methylbenzenesulfonyl)-1,2,3-triazole (1253966-28-7) → 4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide (1620066-67-2)

Guidance literature:

1-methylindole; 4-ethyloxy-1-(4-methylbenzenesulfonyl)-1,2,3-triazole; In 1,2-dichloro-ethane; at 80 ℃; for 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;

With amberlyst 15; In water; 1,2-dichloro-ethane; at 50 ℃; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/ja5058967

Reference yield:

4-toluenesulfonyl azide (941-55-9) → 4-methyl-N-(2-(1-methyl-1H-indol-3-yl)-2-oxoethyl)benzenesulfonamide (1620066-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(I) thiophene-2-carboxylate / toluene / 0 - 20 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane / 0.25 h / 80 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2.2: amberlyst 15 / 50 °C / Inert atmosphere; Sealed tube

With copper(I) thiophene-2-carboxylate; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/ja5058967

upstream raw materials:

1-methylindole

4-phenoxy-1-tosyl-1H-1,2,3-triazole

4-toluenesulfonyl azide

indole