2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine

Base Information

• Chemical Name: 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine
• CAS No.: 80493-81-8
• Molecular Formula: C₁₄H₁₁N₃O₂
• Molecular Weight: 253.26
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80587703
• Wikidata: Q82480205
• Mol file: 80493-81-8.mol

Synonyms:80493-81-8;2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine;2-(2H-1,3-Benzodioxol-5-yl)imidazo[1,2-a]pyridin-3-amine;2-(Benzo[d][1,3]dioxol-5-yl)imidazo[1,2-a]pyridin-3-amine;2-(1,3-benzodioxol-5-yl)imidazo[1,2-a]pyridin-3-amine;MFCD07021268;DTXSID80587703;AKOS005257119;MCULE-1604434791

Chemical Property of 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine

Chemical Property:

• Refractive Index: 1.744
• PSA: 61.78000
• Density: 1.49g/cm³
• LogP: 2.89340
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 253.085126602
• Heavy Atom Count: 19
• Complexity: 341

Purity/Quality:

97% ^*data from raw suppliers

2-BENZO[1,3]DIOXOL-5-YL-IMIDAZO[1,2-A]PYRIDIN-3-YLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1OC2=C(O1)C=C(C=C2)C3=C(N4C=CC=CC4=N3)N

Technology Process of 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine

There total 4 articles about 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H27N3O2 → 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine (80493-81-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1002/jhet.4438

Reference yield:

2-aminopyridine (504-29-0) → 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine (80493-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.33 h / 110 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With hydrogenchloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1002/jhet.4438

Reference yield:

piperonal (120-57-0,30024-74-9) → 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine (80493-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.33 h / 110 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With hydrogenchloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1002/jhet.4438

upstream raw materials:

2-aminopyridine

potassium cyanide

sodium benzo[d][1,3]dioxol-5-yl(hydroxy)methanesulfonate

piperonal

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