4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

Base Information

Chemical Name:4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid
CAS No.:1616371-54-0
Molecular Formula:C₂₁H₂₂ClN₃O₂
Molecular Weight:383.878
Hs Code.:

Synonyms:4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

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Chemical Property of 4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

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Technology Process of 4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

There total 6 articles about 4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616372-00-9
4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616371-54-0
4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; for 3h; Reflux;

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616371-54-0
4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 9 h / 0 - 25 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 h / 100 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 17 h / 115 °C / Inert atmosphere; Sealed tube

6.1: sodium hydroxide; water / ethanol / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; carbon tetrabromide; water; sodium hydride; sodium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 3937-49-3
(trans-4-methylcyclohexyl)methanol

: 1616371-54-0
4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 h / 100 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 17 h / 115 °C / Inert atmosphere; Sealed tube

5.1: sodium hydroxide; water / ethanol / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; water; sodium hydride; sodium carbonate; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;