3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 123884-04-8
• Molecular Formula: C₃₇H₃₄N₂O₆
• Molecular Weight: 602.687

Synonyms:3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property of 3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 3 articles about 3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N3-benzoyl thymidine (94189-75-0) → 3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (123884-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 18 h

2: silver oxide / 3 h / Heating

With dmap; triethylamine; silver(l) oxide; In dichloromethane;

DOI:10.1021/jo00290a024

Reference yield:

trityl chloride (76-83-5) → 3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (123884-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 18 h

2: silver oxide / 3 h / Heating

With dmap; triethylamine; silver(l) oxide; In dichloromethane;

DOI:10.1021/jo00290a024

Reference yield:

5'-O-trityl 3-N-benzoylthymidine (123884-03-7) + methyl iodide (74-88-4) → 3-Benzoyl-1-((2R,4S,5R)-4-methoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (123884-04-8)

Guidance literature:

With silver(l) oxide; for 3h; Yield given; Heating;

DOI:10.1021/jo00290a024

upstream raw materials:

5'-O-trityl 3-N-benzoylthymidine

methyl iodide

N³-benzoyl thymidine

trityl chloride

Downstream raw materials:

3'-O-methylthymidine

3'-O-methyl-5'-O-tritylthymidine

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