dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate

Base Information

Chemical Name:dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS No.:126799-97-1
Molecular Formula:C₁₃H₁₂BrN₃O₄
Molecular Weight:354.16
Hs Code.:
Mol file:126799-97-1.mol

Synonyms:dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate

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Chemical Property of dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate

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Technology Process of dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate

There total 4 articles about dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 107047-10-9
p-bromobenzylazide

: 762-42-5
dimethyl acetylenedicarboxylate

: 126799-97-1
dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate

Guidance literature:: at 120 ℃;
DOI:10.1016/j.bioorg.2021.104654

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 126799-97-1
dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 1 h

2: [(diisopropyl malonamide)2Cu(acetonitrile)]BF₄ / 1 h / 20 °C / Inert atmosphere; Schlenk technique

With sodium azide; [(diisopropyl malonamide)2Cu(acetonitrile)]BF₄; In dimethyl sulfoxide;
DOI:10.1039/c5dt01312g

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 126799-97-1
dimethyl 1-(4-bromobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol

2: phosphorus tribromide / dichloromethane

3: sodium azide / water; acetone

4: 120 °C

With methanol; sodium tetrahydroborate; sodium azide; phosphorus tribromide; In dichloromethane; water; acetone;
DOI:10.1016/j.bioorg.2021.104654