di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

Base Information

• Chemical Name: di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate
• CAS No.: 1417890-00-6
• Molecular Formula: C₅₄H₈₄N₈O₁₄S
• Molecular Weight: 1101.37

Synonyms:di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

Chemical Property of di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

Chemical Property:

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Technology Process of di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

There total 6 articles about di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate (1417889-98-5) + tert-butyl 2,2′-(2-(2-((4-sulfamoylphenethylamino)-methyl)-1H-imidazol-1-yl)acetylazanediyl)diacetate (1446011-66-0) → di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate (1417890-00-6)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm3015348

Reference yield:

4-(2-aminoethyl)benzenesulfonamide (35303-76-5) → di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate (1417890-00-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 75 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere

3: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1021/jm3015348

Reference yield:

tert-butyl 2,2′-(2-(2-formyl-1H-imidazol-1-yl)-acetylazanediyl)diacetate (1228647-94-6) → di-tert-butyl 4-(2-(2-((((1-(2-(bis(2-(tert-butoxy)-2-oxoethyl)-amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate (1417890-00-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 75 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere

3: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1021/jm3015348

upstream raw materials:

4-(2-aminoethyl)benzenesulfonamide

tert-butyl 2,2′-(2-(2-formyl-1H-imidazol-1-yl)-acetylazanediyl)diacetate

di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate

tert-butyl 2,2′-(2-(2-((4-sulfamoylphenethylamino)-methyl)-1H-imidazol-1-yl)acetylazanediyl)diacetate

Downstream raw materials:

C₃₄H₄₄N₈O₁₄S

4-(2-(2-((((1-(2-(bis(carboxymethyl)amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)(4-sulfamoylphenethyl)amino)methyl)-1H-imidazol-1-yl)acetamido)-4-(2-carboxyethyl)heptanedioic acid rhenium tricarbonyl complex

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