(S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate
• CAS No.: 342645-83-4
• Molecular Formula: C₂₀H₂₈O₄S
• Molecular Weight: 364.506
• Mol file: 342645-83-4.mol

Synonyms:(S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate

Chemical Property of (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate

There total 1 articles about (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate (66774-80-9,111924-49-3) → (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate (342645-83-4)

Guidance literature:

With dipyridinium dichromate; pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ja003976k

Reference yield: 76.0%

(bromomethyl)triphenyl phosphonium bromide (1034-49-7) + (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate (342645-83-4) → (1R,4E,3aR,7aR)-4-bromomethylene-7a-methyl-1-[(1S)-methyl-2-p-toluenesulfonyloxyethyl]perhydroindene (173388-39-1)

Guidance literature:

(bromomethyl)triphenyl phosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

(S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/ol035922w

Reference yield: 66.0%

[3R-(1Z,3β,4α,5α)]-[2-[3,5-bis[(1,1-dimethylethyl)dimethylsilyloxy]-4-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide (200636-54-0) + (S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate (342645-83-4) → (1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate (342645-07-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; toluene; at -50 ℃; for 0.5h;

DOI:10.1021/ja003976k

upstream raw materials:

(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

Downstream raw materials:

(1R,4E,3aR,7aR)-4-bromomethylene-7a-methyl-1-[(1S)-methyl-2-p-toluenesulfonyloxyethyl]perhydroindene

(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

(S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,4S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methyl-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methylene-dihydro-furan-2-one