(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate
CAS No.:342645-07-2
Molecular Formula:C₅₀H₈₈O₇SSi₃
Molecular Weight:917.567
Hs Code.:

(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

Synonyms:(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

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Chemical Property of (1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

There total 10 articles about (1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 200636-54-0
[3R-(1Z,3β,4α,5α)]-[2-[3,5-bis[(1,1-dimethylethyl)dimethylsilyloxy]-4-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 342645-83-4
(S)-2-[(1R,3aR,7aR)-octahydro-7a-methyl-4-oxo-4H-inden-1-yl]propyl 4-methylbenzenesulfonate

: 342645-07-2
(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; toluene; at -50 ℃; for 0.5h;
DOI:10.1021/ja003976k

Reference yield:

: 342644-91-1
[3R-(1Z,3β,4α,5α)]-2-[3,5-bis[(1,1-dimethylethyl)dimethylsilyloxy]-4-(3-hydroxypropoxy)-2-methylenecyclohexylidene]ethanol

: 342645-07-2
(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / NCS; Me₂S / CH₂Cl₂ / 0.67 h

2: 92 percent / imidazole / dimethylformamide / 0.25 h / 20 °C

3: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -50 °C

4: 86 mg / aq. H₂O₂ / CHCl₃ / 0.02 h

5: 66 percent / n-butyllithium / tetrahydrofuran; toluene / 0.5 h / -50 °C

With 1H-imidazole; N-chloro-succinimide; n-butyllithium; dimethylsulfide; dihydrogen peroxide; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja003976k

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 342645-07-2
(1α,2β,3β,5Z,7E,20S)-1,3-bis[(1,1-dimethylethyl)dimethyl-silyloxy]-2-[3-[(1,1-dimethylethyl)dimethylsilyloxy]propoxy]-9,10-secopregna-5,7,10(19)-triene-20-methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / pyridinium p-toluenesulfonate; pyridinium dichromate / CH₂Cl₂ / 6 h / 20 °C

2: 66 percent / n-butyllithium / tetrahydrofuran; toluene / 0.5 h / -50 °C

With dipyridinium dichromate; n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja003976k