5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Chemical Name:5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide
CAS No.:1454666-69-3
Molecular Formula:C₂₄H₂₁F₃N₆O₂S
Molecular Weight:514.531
Hs Code.:

Synonyms:5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Chemical Property of 5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Technology Process of 5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

There total 4 articles about 5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454667-32-3
5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 1454667-36-7
2-oxo-N-(pyrimidin-2-yl)oxazolidine-3-sulfonamide

: 1454666-69-3
5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: With triethylamine; In acetonitrile; at 130 ℃; for 0.5h; Microwave irradiation; Sealed tube;

Reference yield:

: 640280-28-0
1-bromo-2-iodo-4-(trifluoromethyl)benzene

: 1454666-69-3
5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere; Sealed tube

2.1: n-butyllithium / diethyl ether; hexane / 1.02 h / Cooling with acetone-dry ice

2.2: 1 h

3.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere; Microwave irradiation

4.1: triethylamine / acetonitrile / 0.5 h / 130 °C / Microwave irradiation; Sealed tube

With potassium phosphate; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); triethylamine; In 1,4-dioxane; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1423161-92-5
(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)boronic acid

: 1454666-69-3
5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere; Microwave irradiation

2: triethylamine / acetonitrile / 0.5 h / 130 °C / Microwave irradiation; Sealed tube

With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); triethylamine; In 1,4-dioxane; water; acetonitrile;