5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1454667-32-3
Molecular Formula:C₂₀H₁₈F₃N₃
Molecular Weight:357.378
Hs Code.:

Synonyms:5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about 5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 923591-51-9
5-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1423161-92-5
(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)boronic acid

: 1454667-32-3
5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 90 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 640280-28-0
1-bromo-2-iodo-4-(trifluoromethyl)benzene

: 1454667-32-3
5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere; Sealed tube

2.1: n-butyllithium / diethyl ether; hexane / 1.02 h / Cooling with acetone-dry ice

2.2: 1 h

3.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; diethyl ether; hexane; water; N,N-dimethyl-formamide;

Reference yield:

: 1423161-91-4
5-(2-bromo-5-(trifluoromethyl)phenyl)-1-methyl-1H-pyrazole

: 1454667-32-3
5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 1.02 h / Cooling with acetone-dry ice

1.2: 1 h

2.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; diethyl ether; hexane; water;