[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester

Base Information

• Chemical Name: [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester
• CAS No.: 934548-15-9
• Molecular Formula: C₂₂H₂₅Cl₂N₃O₅
• Molecular Weight: 482.364
• Mol file: 934548-15-9.mol

Synonyms:[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester

Chemical Property of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester

There total 3 articles about [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

N-(chloromethyloxycarbonyl)glycine diethylamide (934548-23-9) + diclofenac sodium (15307-79-6) → [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester (934548-15-9)

Guidance literature:

With tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/ardp.200600145

Reference yield:

tert-butyl (2-(diethylamino)-2-oxoethyl)carbamate (500871-60-3) → [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester (934548-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / CF₃COOH / CH₂Cl₂ / 0.5 h / 20 °C

2: 45 percent / CH₂Cl₂ / -10 - 20 °C

3: 13 percent / tetrabutylammonium bromide; Et₃N / tetrahydrofuran / 24 h / 20 °C

With tetrabutylammomium bromide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ardp.200600145

Reference yield:

2-amino-N,N-diethylacetamide (34105-57-2) → [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester (934548-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / CH₂Cl₂ / -10 - 20 °C

2: 13 percent / tetrabutylammonium bromide; Et₃N / tetrahydrofuran / 24 h / 20 °C

With tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ardp.200600145

upstream raw materials:

N-(chloromethyloxycarbonyl)glycine diethylamide

diclofenac sodium

tert-butyl (2-(diethylamino)-2-oxoethyl)carbamate

2-amino-N,N-diethylacetamide

Downstream raw materials:

2-amino-N,N-diethylacetamide

[2-(2,6-dichloroanilino)phenyl]acetic acid

Refernces