O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Base Information

Chemical Name:O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate
CAS No.:874292-18-9
Molecular Formula:C₃₇H₄₆N₃O₈P
Molecular Weight:691.761
Hs Code.:

Synonyms:O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

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Chemical Property of O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

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Technology Process of O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

There total 4 articles about O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874292-11-2
O-benzyl 2-propen-1-yl(aminomethyl)phosphinate

: 939984-68-6
(S)-2-((S)-4-Benzyloxycarbonyl-4-benzyloxycarbonylamino-butyrylamino)-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 874292-18-9
O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm050922i

Reference yield:

: 874291-97-1
allylphosphinic acid benzyl ester

: 874292-18-9
O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / BF₃*Et₂O / toluene / 72 h / 20 °C

2: 89 percent / trifluoroacetic acid / CH₂Cl₂ / 0.25 h / 20 °C

3: triethylamine / dimethylformamide / 16 h / 20 °C

With boron trifluoride diethyl etherate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm050922i

Reference yield:

: 874292-04-3
O-benzyl 2-propen-1-yl[(N-tritylamino)methyl]phosphinate

: 874292-18-9
O-benzyl 2-propen-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / trifluoroacetic acid / CH₂Cl₂ / 0.25 h / 20 °C

2: triethylamine / dimethylformamide / 16 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050922i