2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

Base Information

• Chemical Name: 2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester
• CAS No.: 180311-20-0
• Molecular Formula: C₃₈H₂₇NO₃
• Molecular Weight: 545.637
• Mol file: 180311-20-0.mol

Synonyms:2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

Chemical Property of 2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

There total 5 articles about 2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzophenone imine (1013-88-3) → 2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester (180311-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 2.) THF, HMPA, from -78 deg C to RT

With lithium diisopropyl amide; In dichloromethane;

DOI:10.1016/0957-4166(96)00212-1

Reference yield:

tert-Butoxycarbonylamino-acetic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester (180311-13-1) → 2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester (180311-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / conc. aq. HCl / ethyl acetate / 1.5 h / Ambient temperature

2: 96 percent / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) LDA / 1.) THF, -78 deg C, 2.) THF, HMPA, from -78 deg C to RT

With hydrogenchloride; lithium diisopropyl amide; In dichloromethane; ethyl acetate;

DOI:10.1016/0957-4166(96)00212-1

Reference yield:

Amino-acetic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester; hydrochloride → 2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester (180311-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 2.) THF, HMPA, from -78 deg C to RT

With lithium diisopropyl amide; In dichloromethane;

DOI:10.1016/0957-4166(96)00212-1

upstream raw materials:

propargyl bromide

(Benzhydrylidene-amino)-acetic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

Benzophenone imine

tert-Butoxycarbonylamino-acetic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

Downstream raw materials:

(2S)-2-amino-4-pentynoic acid

(R)-2-aminopent-4-ynoic acid