L-Propargylglycine

Base Information

• Chemical Name: L-Propargylglycine
• CAS No.: 23235-01-0
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.116
• Hs Code.: 29224999
• Mol file: 23235-01-0.mol

Synonyms:4-Pentynoicacid, 2-amino-, (S)-;4-Pentynoic acid, 2-amino-, L- (8CI);(S)-2-Amino-4-pentynoic acid;L-2-Amino-4-pentynoic acid;L-2-Propynylglycine;Propargylglycine;

Chemical Property of L-Propargylglycine

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0.00174mmHg at 25°C
• Melting Point: 232oC
• Refractive Index: 1.512
• Boiling Point: 272.052 °C at 760 mmHg
• PKA: 2.04±0.10(Predicted)
• Flash Point: 118.333 °C
• PSA: 63.32000
• Density: 1.21 g/cm³
• LogP: 0.12190
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Propargylglycine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of L-Propargylglycine

There total 19 articles about L-Propargylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-(2,2,5,7,8-Pentamethyl-chroman-6-sulfonylamino)-5-trimethylsilanyl-pent-4-ynoic acid (207459-88-9) → (R)-2-aminopent-4-ynoic acid (23235-01-0,23235-03-2,50428-03-0,64165-64-6)

Guidance literature:

With trifluoroacetic acid; Heating;

DOI:10.1039/c39940000943

Reference yield: 88.8%

N-Acetyl-α-propargylglycine (23235-02-1,23235-04-3,23234-80-2) → (2S)-2-amino-4-pentynoic acid (23235-01-0) + (R)-2-aminopent-4-ynoic acid (23235-01-0,23235-03-2,50428-03-0,64165-64-6)

Guidance literature:

at 37 ℃; for 21h;

DOI:10.1021/jm00366a015

Reference yield: 88.8%

N-Acetyl-α-propargylglycine (23235-02-1,23235-04-3,23234-80-2) → (2S)-2-amino-4-pentynoic acid (23235-01-0) + (R)-2-aminopent-4-ynoic acid (23235-01-0,23235-03-2,50428-03-0,64165-64-6)

Guidance literature:

at 37 ℃; for 21h;

DOI:10.1021/jm00366a015

upstream raw materials:

N-Acetyl-α-propargylglycine

(2R,5S)-5-isopropyl-3,6-dimethoxy-2-propargyl-2,5-dihydropyrazine

2-(Benzhydrylidene-amino)-pent-4-ynoic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

propargyl bromide

Downstream raw materials:

Boc-L-Pra-OH

tert-butyl D-propargylglycinate

(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pent-4-ynoic acid

methyl (2S)-2-(tert-butoxycarbonylamino)pent-4-ynoate

Refernces

• 1、 -. "DL-propargyl glycine intermediate and preparation method thereof, and propargyl glycine preparation method based on intermediate". Page/Page column 6-8. . Retrieved 2020/06/20.
• 2、 Sun, Guodong,Wei, Mingjie,Luo, Zhonghua,Liu, Yongjun,Chen, Zhijun,Wang, Zhongqing. "An Alternative Scalable Process for the Synthesis of the Key Intermediate of Omarigliptin". supporting information. p. 2074 - 2079. Retrieved 2016/12/24.