tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

Base Information

Chemical Name:tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate
CAS No.:120230-81-1
Molecular Formula:C₁₉H₂₇NO₅
Molecular Weight:349.427
Hs Code.:

Synonyms:tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

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Chemical Property of tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

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Technology Process of tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

There total 4 articles about tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 120230-79-7
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-hydroxybutanoate

: 120230-81-1
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

Guidance literature:: With N-chloro-succinimide; dimethylsulfide; In toluene; at -25 ℃; for 4h;
DOI:10.1021/jo00274a037

Reference yield:

: 120230-78-6
tert-butyl (2S,3S)-2-<(9-phenylfluorenyl)amino>-3-isopropyl-4-hydroxybutanoate

: 120230-81-1
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, HOAc / 10percent Pd/C / methanol / 760 Torr

2: NaHCO₃ / ethyl acetate; H₂O / 1.5 h / 0 °C

3: 80 percent / N-chlorosuccinimide (NCS), (CH₃)2S / toluene / 4 h / -25 °C

With N-chloro-succinimide; dimethylsulfide; hydrogen; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In methanol; water; ethyl acetate; toluene;
DOI:10.1021/jo00274a037

Reference yield:

: 120230-44-6
2-N-(9-phenylfluorenyl)-3-isopropyl-L-aspartic acid α-tert-butyl β-methyl diester

: 120230-81-1
tert-butyl (2S,3S)-2-<(benzoxycarbonyl)amino>-3-isopropyl-4-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / diisobutylaluminum hydride (DIBAL) / toluene; hexane / 0.33 h / -30 °C

2: H₂, HOAc / 10percent Pd/C / methanol / 760 Torr

3: NaHCO₃ / ethyl acetate; H₂O / 1.5 h / 0 °C

4: 80 percent / N-chlorosuccinimide (NCS), (CH₃)2S / toluene / 4 h / -25 °C

With N-chloro-succinimide; dimethylsulfide; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In methanol; hexane; water; ethyl acetate; toluene;
DOI:10.1021/jo00274a037