5-methyl-BAPTA tetraethyl ester

Base Information

• Chemical Name: 5-methyl-BAPTA tetraethyl ester
• CAS No.: 96315-09-2
• Molecular Formula: C₃₁H₄₂N₂O₁₀
• Molecular Weight: 602.682
• Mol file: 96315-09-2.mol

Synonyms:5-methyl-BAPTA tetraethyl ester

Chemical Property of 5-methyl-BAPTA tetraethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-BAPTA tetraethyl ester

There total 5 articles about 5-methyl-BAPTA tetraethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.4%

ethyl bromoacetate (105-36-2) + 1-(2'-amino-5'-methylphenoxy)-2-(2''-aminophenoxy)ethane (96331-95-2) → 5-methyl-BAPTA tetraethyl ester (96315-09-2)

Guidance literature:

With disodium hydrogenphosphate; sodium iodide; In acetonitrile; for 18h; Inert atmosphere; Reflux;

DOI:10.1039/b905571a

Reference yield:

2-nitro-5-methylphenol (700-38-9) → 5-methyl-BAPTA tetraethyl ester (96315-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / Inert atmosphere

2: 10% palladium on activated charcoal; hydrogen / ethanol / Inert atmosphere

3: potassium carbonate / Inert atmosphere

With 10% palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol;

DOI:10.1039/c1cc11081k

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → 5-methyl-BAPTA tetraethyl ester (96315-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / Inert atmosphere

2: 10% palladium on activated charcoal; hydrogen / ethanol / Inert atmosphere

3: potassium carbonate / Inert atmosphere

With 10% palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol;

DOI:10.1039/c1cc11081k

upstream raw materials:

ethyl bromoacetate

1-(2'-amino-5'-methylphenoxy)-2-(2''-aminophenoxy)ethane

2-nitro-5-methylphenol

2-hydroxynitrobenzene

Downstream raw materials:

5-aldehyde-5'-methyl-BAPTA tetraethyl ester

5-bromo-5'-methyl-BAPTA ethyl ester

Refernces

• 1、 Bhattacharyya, Koyel X.,Boubekeur-Lecaque, Le?la,Tapsoba, Issa,Maisonhaute, Emmanuel,Sch?llhorn, Bernd,Amatore, Christian. "Water-soluble, redox-active organometallic calcium chelators". supporting information. p. 14257 - 14264. Retrieved 2013/04/10.
• 2、 Dong, Xiaohu,Yang, Yiyao,Sun, Jian,Liu, Zhihong,Liu, Bi-Feng. "Two-photon excited fluorescent probes for calcium based on internal charge transfer". supporting information; experimental part. p. 3883 - 3885. Retrieved 2010/01/06.