(S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester

Base Information

Chemical Name:(S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester
CAS No.:204765-31-1
Molecular Formula:C₂₄H₃₇NO₅
Molecular Weight:419.561
Hs Code.:

Synonyms:(S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester

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Chemical Property of (S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester

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Technology Process of (S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester

There total 3 articles about (S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 125814-33-7
N-(tert-butoxycarbonyl)-L-leucine N-carboxyanhydride

: 77509-00-3
phenylmethyl 4-methylpentanoate

: 204765-31-1
(S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(98)00026-4

Reference yield:

: 54430-65-8
(S)-tert-butyl 1-(1H-imidazol-1-yl)-4-methyl-1-oxopentan-2-ylcarbamate

: 77509-00-3
phenylmethyl 4-methylpentanoate

: 204765-31-1
(S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester

Guidance literature:: phenylmethyl 4-methylpentanoate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

(S)-tert-butyl 1-(1H-imidazol-1-yl)-4-methyl-1-oxopentan-2-ylcarbamate; In tetrahydrofuran; at -78 ℃; for 0.5h; Further stages.;
DOI:10.1021/ol016331d

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 204765-31-1
(S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / cooling

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 0.5 h / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/ol016331d