77509-00-3

Upstream product

• 15795-47-8 2,2-dimethyl-5-(2-methylpropylidene)-1,3-dioxane-4,6-dione 
• 100-39-0 benzyl bromide 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 75-30-9 2-iodo-propane 
• 2495-35-4 benzylacrylate 
• 759-05-7 3-methyl-2-ketobutanoic acid 
• 646-07-1 4-Methylpentanoic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 189030-84-0 (R)-2-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-4-methyl-pentanoic acid ((S)-1-hydroxymethyl-2-phenyl-ethyl)-amide 
• 189030-86-2 (S)-2-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-4-methyl-pentanoic acid ((S)-1-hydroxymethyl-2-phenyl-ethyl)-amide 
• 189030-79-3 2-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-4-methyl-pentanoic acid benzyl ester 
• 189030-78-2 3-(R)-benzyloxycarbonyl-5-methylhexanoic acid 
• 211308-50-8 (2S,3R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentanoic acid benzyl ester 
• 211308-49-5 benzyl (2S,3R)-2,3-dihydroxy-4-methylpentanoate 
• 131401-46-2 (E)-4-methyl-pent-2-enoic acid benzyl ester 
• 204765-31-1 (S)-4-tert-Butoxycarbonylamino-2-isobutyl-6-methyl-3-oxo-heptanoic acid benzyl ester 

Relevant academic research and scientific papers

Visible-light-initiated manganese-catalyzed Giese addition of unactivated alkyl iodides to electron-poor olefins

Herein, we report a mild protocol for direct visible-light-initiated Giese addition of unactivated alkyl iodides to electron-poor olefins (Michael acceptors) with catalysis by decacarbonyl dimanganese, Mn2(CO)10, an inexpensive earth-abundant-metal catalyst. This protocol is compatible with a wide array of sensitive functional groups and has a broad substrate scope with regard to both the alkyl iodide and the Michael acceptor.

Direct Decarboxylative-Decarbonylative Alkylation of α-Oxo Acids with Electrophilic Olefins via Visible-Light Photoredox Catalysis

The decarbonylation of primary, secondary, and tertiary alkyl-substituted acyl radicals has been investigated through photoredox catalysis. A series of quaternary carbons and γ-ketoesters have been directly constructed by the photoredox 1,4-conjugate addi

Nucleophilic trifluoromethylation of arylidene Meldrum's acids

A method for the trifluoromethylation of arylidene Meldrum's acids using Me3SiCF3 followed by transformation of the initial products to CF3-substituted esters and alcohols is described. The sequence of reactions is perform

Exploration of the importance of the P2-P3-NHCO-moiety in a potent di- or tripeptide inhibitor of calpain I: insights into the development of nonpeptidic inhibitors of calpain I.

Calpain I, an intracellular cysteine protease, has been implicated in the neurodegeneration following an episode of cerebral ischemia. In this paper, we report on a series of peptidomimetic ketomethylene and carbamethylene inhibitors of recombinant human calpain I (rh calpain I). Our study reveals that the -NHCO-moiety (possible hydrogen-bonding site) at the P2-P3 region of a potent tripeptide or a dipeptide inhibitor of calpain I is not a strict requirement for enzyme recognition. Compounds 7d ((R)-2-isobutyl-4-oxo-4-(9-xanthenyl)butanoic acid ((S)-1-formyl-3-methyl)butyl amide), 31 ((R)-2-isobutyl-4-(2-sulfonylnaphthyl)butyric acid ((S)1-formyl-3-methyl)butyl amide) and 34 ((R)-2-isobutyl-4-(2-sulfoxylnaphthyl)butyric acid ((S)-1-formyl-3-methyl)butyl amide) which exhibited good activity in the enzyme assay, also inhibited calpain I in a human cell line.

Synthesis of the antibiotically active part of agrocin 84

Phosphitylation of bis-O-silylated threo-2,3-dihydroxy-4- methylpentanamide and condensation of the resulting N-acylphosphorodiamidite with 2'-O-acetyl-3'-deoxyarabinoadenosine led, after oxidation and deprotection, to the isolation of the title compound.