(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate

Base Information

Chemical Name:(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate
CAS No.:1187450-75-4
Molecular Formula:C₂HF₃O₂*C₂₃H₂₁N₅O₄S₂
Molecular Weight:609.607
Hs Code.:

Synonyms:(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate

There total 11 articles about (6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1187450-47-0
tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

: 76-05-1
trifluoroacetic acid

: 1187450-75-4
(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate

Guidance literature:: tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 203321-86-2
6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

: 1187450-75-4
(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 1.17 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: ethanol; calcium chloride; sodium tetrahydroborate / Tetraethylene glycol dimethyl ether / 0.92 h / 20 °C / Cooling with ice

2.2: 1.17 h / 20 °C / Cooling with ice

3.1: tributylphosphine; diamide / tetrahydrofuran / 11 h / 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; tributylphosphine; diamide; sodium hydride; calcium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; Tetraethylene glycol dimethyl ether; N,N-dimethyl-formamide; mineral oil; 3.1: Mitsunobu reaction;

Reference yield:

: 1187450-49-2
tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate

: 1187450-75-4
(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: tributylphosphine; diamide / tetrahydrofuran / 11 h / 20 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; tributylphosphine; diamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1: Mitsunobu reaction;