Acetic acid, 5-3-2-(3,4-dimethoxyphenyl)ethyl(phenylmethoxy)carbonylamino-2-hydroxypropoxy-1,2,3,4-tetrahydro-2-oxo-8-quinolinyloxy-

Base Information

• Chemical Name: Acetic acid, 5-3-2-(3,4-dimethoxyphenyl)ethyl(phenylmethoxy)carbonylamino-2-hydroxypropoxy-1,2,3,4-tetrahydro-2-oxo-8-quinolinyloxy-
• CAS No.: 80090-30-8
• Molecular Formula: C32H36 N2 O10
• Molecular Weight: 608.64
• Mol file: 80090-30-8.mol

Synonyms:Acetic acid,[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl][(phenylmethoxy)carbonyl]amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2-oxo-8-quinolinyl]oxy]-(9CI)

Chemical Property of Acetic acid, 5-3-2-(3,4-dimethoxyphenyl)ethyl(phenylmethoxy)carbonylamino-2-hydroxypropoxy-1,2,3,4-tetrahydro-2-oxo-8-quinolinyloxy-

Chemical Property:

• Melting Point: 141-143 °C(Solv: methanol (67-56-1))
• Boiling Point: 859.8±65.0 °C(Predicted)
• PKA: 3.10±0.10(Predicted)
• PSA: 153.09000
• Density: 1.308±0.06 g/cm3(Predicted)
• LogP: 3.81110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, 5-3-2-(3,4-dimethoxyphenyl)ethyl(phenylmethoxy)carbonylamino-2-hydroxypropoxy-1,2,3,4-tetrahydro-2-oxo-8-quinolinyloxy-

There total 9 articles about Acetic acid, 5-3-2-(3,4-dimethoxyphenyl)ethyl(phenylmethoxy)carbonylamino-2-hydroxypropoxy-1,2,3,4-tetrahydro-2-oxo-8-quinolinyloxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.9%

8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (80090-29-5) → 5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-carboxymethoxy-3,4-dihydrocarbostyril (80090-30-8)

Guidance literature:

With sodium hydroxide; In methanol; for 0.25h; Ambient temperature;

DOI:10.1248/cpb.29.2166

Reference yield:

5,8-Dihydroxy-3,4-dihydro-2(1H)-quinolinone (59430-56-7) → 5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-carboxymethoxy-3,4-dihydrocarbostyril (80090-30-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 48 percent / K₂CO₃ / acetone; H₂O / 4 h / Heating

2: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

3: 43.6 percent / methanol / 20 h / Ambient temperature

4: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

5: 96 percent / 10percent Na₂CO₃, NaOH / acetone; H₂O / 1.5 h / Ambient temperature

6: 100 percent / 2N NaOH / methanol / Ambient temperature

7: 73.8 percent / K₂CO₃ / acetone; H₂O / 9 h / Ambient temperature

8: 79.9 percent / 2N NaOH / methanol / 0.25 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol; acetone;

DOI:10.1248/cpb.29.2166

Reference yield:

8-(Benzyloxy)-5-hydroxy-3,4-dihydro-2(1H)-quinolinone (59826-16-3) → 5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-carboxymethoxy-3,4-dihydrocarbostyril (80090-30-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

2: 43.6 percent / methanol / 20 h / Ambient temperature

3: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

4: 96 percent / 10percent Na₂CO₃, NaOH / acetone; H₂O / 1.5 h / Ambient temperature

5: 100 percent / 2N NaOH / methanol / Ambient temperature

6: 73.8 percent / K₂CO₃ / acetone; H₂O / 9 h / Ambient temperature

7: 79.9 percent / 2N NaOH / methanol / 0.25 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol; acetone;

DOI:10.1248/cpb.29.2166

upstream raw materials:

8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

5,8-Dihydroxy-3,4-dihydro-2(1H)-quinolinone

8-(Benzyloxy)-5-hydroxy-3,4-dihydro-2(1H)-quinolinone

8-benzyloxy-5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

Downstream raw materials:

8-carboxymethoxy-5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

Refernces