3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

Base Information

Chemical Name:3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid
CAS No.:944154-49-8
Molecular Formula:C₂₀H₁₅ClF₂N₂O₄S
Molecular Weight:452.866
Hs Code.:

Synonyms:3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

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Chemical Property of 3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

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Technology Process of 3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

There total 6 articles about 3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 3-[4-[(2,4-difluorobenzyl)oxy]-2-(methylthio)-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoic acid

: 944154-49-8
3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

Guidance literature:: With dichloro-acetic acid; N-chloro-succinimide; In 1,1-dichloroethane; at 65 ℃; for 3h;

Reference yield:

: 773104-00-0
methyl 3-[(aminocarbonothioyl)amino]-4-methylbenzoate

: 944154-49-8
3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 0 °C / Reflux

2: 4-methyl-morpholine / dichloromethane / -5 - 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

4: sodium hydroxide; water / 1,4-dioxane / 1.5 h / 20 °C

5: N-chloro-succinimide; dichloro-acetic acid / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere

With 4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; water; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1093071-69-2
C₁₁H₁₆N₂O₂S

: 944154-49-8
3-[5-chloro-4-(2,4-difluoro-benzyloxy)-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / dichloromethane / -5 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

3: sodium hydroxide; water / 1,4-dioxane / 1.5 h / 20 °C

4: N-chloro-succinimide; dichloro-acetic acid / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere

With 4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; water; potassium carbonate; sodium hydroxide; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;