ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate

Base Information

Chemical Name:ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate
CAS No.:859213-21-1
Molecular Formula:C₂₀H₂₅F₃N₂O₅
Molecular Weight:430.424
Hs Code.:

Synonyms:ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate

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Chemical Property of ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate

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Technology Process of ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate

There total 1 articles about ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859027-01-3
4-bromomethyl-3-trifluoromethyl-benzoic acid ethyl ester

: 92235-34-2
(2-oxopyrrolidin-3-(S)-yl)carbamic acid tert-butyl ester

: 859213-21-1
ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate

Guidance literature:: (2-oxopyrrolidin-3-(S)-yl)carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

4-bromomethyl-3-trifluoromethyl-benzoic acid ethyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 859213-21-1
ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate

: 859213-20-0
4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoic acid

Guidance literature:: ethyl 4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethylbenzoate; With sodium hydroxide; water; In methanol; at 20 ℃; for 20h;

With hydrogenchloride; In methanol; water;