2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: 2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester
• CAS No.: 910033-07-7
• Molecular Formula: C₁₈H₂₀O₄
• Molecular Weight: 300.354
• Mol file: 910033-07-7.mol

Synonyms:2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester

Chemical Property of 2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester

There total 2 articles about 2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyllactic acid (828-01-3) → 2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester (910033-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / 16 h / Heating

2: NaH, Bu₄NI / dimethylformamide / 16 h / Ambient temperature

With sulfuric acid; tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00357-0

Reference yield:

methyl 2-hydroxy-3-phenylpropanoate (13674-16-3) + p-methoxybenzyl chloride (824-94-2) → 2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester (910033-07-7)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; for 16h; Yield given; Ambient temperature;

DOI:10.1016/S0960-894X(97)00357-0

Reference yield: 89.0%

2-(4-Methoxy-benzyloxy)-3-phenyl-propionic acid methyl ester (910033-07-7) → 2-(4-Methoxy-benzyloxy)-3-phenyl-propan-1-ol (195703-06-1)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/S0960-894X(97)00357-0

upstream raw materials:

methyl 2-hydroxy-3-phenylpropanoate

p-methoxybenzyl chloride

phenyllactic acid

Downstream raw materials:

2-(4-Methoxy-benzyloxy)-3-phenyl-propan-1-ol

methyl 2-hydroxy-3-phenylpropanoate