methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

Base Information

Chemical Name:methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate
CAS No.:93921-10-9
Molecular Formula:C₂₃H₂₃N₃O₈S₂
Molecular Weight:533.583
Hs Code.:

Synonyms:methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

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Chemical Property of methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

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Technology Process of methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

There total 1 articles about methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 93921-10-9
methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

Guidance literature:

Reference yield: 83.0%

: 93921-10-9
methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

: 95406-19-2
3-Chloromethyl-2-[2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid methyl ester

Guidance literature:: With sulfuric acid; sodium chloride; In chloroform; water; at 7 - 12 ℃; for 1.3h;
DOI:10.1016/S0040-4039(00)87295-0

Reference yield:

: 93921-10-9
methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

: 53638-84-9,84927-02-6
3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / NaCl-H₂SO₄ / CHCl₃; H₂O / 1.3 h / 7 - 12 °C

2: 74 percent / NH₃ / dimethylformamide / 1 h / -30 - -20 °C / investigation of cyclization with following bases: AcONa, Et₃N, KOH, KI

With sulfuric acid; ammonia; sodium chloride; In chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)87295-0