(6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester
• CAS No.: 53638-84-9
• Molecular Formula: C₁₇H₁₇ClN₂O₄S
• Molecular Weight: 380.852

Synonyms:(6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester

Chemical Property of (6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester

There total 9 articles about (6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-chloromethyl-but-3-enoic acid methyl ester (95406-16-9) → 3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester (53638-84-9,84927-02-6)

Guidance literature:

With ammonia; In N,N-dimethyl-formamide; at -30 - -20 ℃; for 1h;

DOI:10.1016/S0040-4039(00)87295-0

Reference yield: 82.0%

(R)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-chloromethyl-but-3-enoic acid methyl ester (82895-16-7) → (6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester (53638-84-9)

Guidance literature:

With ammonia; In N,N-dimethyl-formamide; at -30 - -20 ℃; for 1h;

DOI:10.1002/bscb.19820911202

Reference yield: 74.0%

(R)-3-Chloromethyl-2-[(2R,3R)-2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid methyl ester (82895-15-6) → (6R)-3-chloromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester (53638-84-9)

Guidance literature:

With ammonia; In N,N-dimethyl-formamide; at -30 - -20 ℃; for 1h;

DOI:10.1002/bscb.19820911202

upstream raw materials:

2-(2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-chloromethyl-but-3-enoic acid methyl ester

3-Chloromethyl-2-[2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid methyl ester

2-(2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-methyl-but-3-enoic acid methyl ester

methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate

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