(1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide

Base Information

Chemical Name:(1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide
CAS No.:1315338-46-5
Molecular Formula:C₂₆H₂₈N₂O₇S
Molecular Weight:512.584
Hs Code.:

Synonyms:(1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide

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Chemical Property of (1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide

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Technology Process of (1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide

There total 8 articles about (1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1315338-44-3
(1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-4-nitro-benzenesulfonamide

: 107-30-2
chloromethyl methyl ether

: 1315338-46-5
(1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide

Guidance literature:: (1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-4-nitro-benzenesulfonamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

chloromethyl methyl ether; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.04.008

Reference yield:

: 1345820-59-8
[(R)-1-[(R)-(tert-butyldimethylsilanyloxy)(phenyl)methyl]-3-(3,4-dimethoxyphenyl)propyl]carbamic acid tert-butyl ester

: 1315338-46-5
(1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.25 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 80 °C / Inert atmosphere; Neat (no solvent)

3.1: triethylamine / 3 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 5 °C / Inert atmosphere

4.2: 2.5 h / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; mineral oil; 2.1: Friedel Crafts alkylation;
DOI:10.1016/j.tetasy.2011.08.014

Reference yield:

: 1345820-58-7
[(R)-1-[(R)-(tert-butyldimethylsilanyloxy)phenylmethyl]-3-(3,4-dimethoxyphenyl)allyl]carbamic acid tert-butyl ester

: 1315338-46-5
(1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1.5 h / 20 °C / 760.05 Torr

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.25 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / 80 °C / Inert atmosphere; Neat (no solvent)

4.1: triethylamine / 3 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 5 °C / Inert atmosphere

5.2: 2.5 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; mineral oil; 3.1: Friedel Crafts alkylation;
DOI:10.1016/j.tetasy.2011.08.014