1315338-44-3

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 406174-91-2 (1R,2R)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylamine 
• 1428650-49-0 (R)-tert-Butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-phenylbutan-2-yl)carbamate 
• 1428650-45-6 (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate 
• 1260604-96-3 (R)-2-((tert-butoxycarbonyl)amino)-4-(3,4-dimethoxyphenyl)butanoic acid 
• 1428650-47-8 (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-hydroxybutan-2-yl)carbamate 
• 710314-45-7 trans-(1R,2R)-6,7-dimethoxy-2-nitro-1-phenyl-1,2,3,4-tetrahydronaphthalene 
• 1345820-54-3 [(R)-3-(3,4-dimethoxyphenyl)-1-(R)-(hydroxy(phenyl)methyl)propyl]carbamic acid tert-butyl ester 
• 1345820-58-7 [(R)-1-[(R)-(tert-butyldimethylsilanyloxy)phenylmethyl]-3-(3,4-dimethoxyphenyl)allyl]carbamic acid tert-butyl ester 
• 1345820-59-8 [(R)-1-[(R)-(tert-butyldimethylsilanyloxy)(phenyl)methyl]-3-(3,4-dimethoxyphenyl)propyl]carbamic acid tert-butyl ester 
• 85185-33-7 1,2-dimethoxy-4-(4-phenyl-but-3-enyl)benzene 
• 149552-43-2 [N-(nosyl)imino]phenyliodinane 

Downstream Products

• 1315338-50-1 (6aR,12bS)-10,11-dimethoxy-6-(4-nitrobenzenesulfonyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine 
• 137417-08-4 (+)-Dihydrexidine hydrochloride 
• 406174-91-2 (1R,2R)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylamine 
• 1315338-46-5 (1R,2R)-N-(6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-methoxymethyl-4-nitro-benzenesulfonamide 
• 1315338-52-3 C₂₈H₃₂N₂O₈S 

Relevant academic research and scientific papers

Divergent asymmetric synthesis of hexahydrobenzophenanthridine dopamine D1 agonists, A-86929, and dihydrexidine

A divergent and scalable asymmetric synthesis of the dopamine D1 agonists, A-86929, and dihydrexidine with high diastereo- and enantioselectivity was accomplished from Weinreb amide 8 derived from inexpensive and easily available l-serine. The synthesis of A-86929 involves only one chromatographic purification.

Rhodium-catalyzed enantioselective conjugate addition of arylboronic acids to dihydronitronaphthalenes

A highly enantioselective (up to 91% ee) rhodium-catalyzed asymmetric addition of arylboronic acids has been achieved leading to the challenging dihydro-3-nitronaphthalenes using one equivalent of phosphoramidite ligand to rhodium catalyst. A concise formal asymmetric synthesis of the dopamine D1 agonist, dihydrexidine was accomplished using the method. Copyright

Asymmetric synthesis of a dopamine D1 agonist, dihydrexidine from d-serine

A scalable asymmetric synthesis of trans-2-amino-6,7-dimethoxy-1- phenyltetralin 2 and its N-nosyl derivative 12 have been achieved from Garner aldehyde derived from easily available d-serine using a stereoselective PhMgBr addition, Wittig reaction and TF

Asymmetric synthesis of the dopamine D1 agonist, dihydrexidine

A concise asymmetric synthesis of first, high affinity domaine D1 full agonist, dihydrexidine has been accomplished via catalytic enantioselective aziridination and subsequent one-pot Friedel-Crafts cyclization of an in situ generated tethered aziridine w