1315338-44-3Relevant articles and documents
Divergent asymmetric synthesis of hexahydrobenzophenanthridine dopamine D1 agonists, A-86929, and dihydrexidine
Malhotra, Rajesh,Chakrabarti, Sagar,Ghosh, Amit,Ghosh, Rajib,Dey, Tushar K.,Dutta, Swarup,Dutta, Shantanu,Roy, Subho,Basu, Sourav,Hajra, Saumen
, p. 278 - 284 (2013/05/08)
A divergent and scalable asymmetric synthesis of the dopamine D1 agonists, A-86929, and dihydrexidine with high diastereo- and enantioselectivity was accomplished from Weinreb amide 8 derived from inexpensive and easily available l-serine. The synthesis of A-86929 involves only one chromatographic purification.
Asymmetric synthesis of a dopamine D1 agonist, dihydrexidine from d-serine
Malhotra, Rajesh,Ghosh, Amit,Ghosh, Rajib,Chakrabarti, Sagar,Dutta, Swarup,Dey, Tushar K.,Roy, Subho,Basu, Sourav,Hajra, Saumen
experimental part, p. 1522 - 1529 (2011/12/14)
A scalable asymmetric synthesis of trans-2-amino-6,7-dimethoxy-1- phenyltetralin 2 and its N-nosyl derivative 12 have been achieved from Garner aldehyde derived from easily available d-serine using a stereoselective PhMgBr addition, Wittig reaction and TF