N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

Base Information

Chemical Name:N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide
CAS No.:121686-52-0
Molecular Formula:C₆₁H₇₁NO₁₁Si
Molecular Weight:1022.32
Hs Code.:

N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

Synonyms:N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

Suppliers and Price of N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

There total 1 articles about N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 100-39-0
benzyl bromide

: 114669-87-3
benzyl 2-acetamido-3,6-di-O-benzyl-4-O-<6-O-(tert-butyldiphenylsilyl)-3,4-O-isopropylidene-β-D-galactopyranosyl>-2-deoxy-α-D-glucopyranoside

: 121686-52-0
N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

Guidance literature:: With silver(l) oxide; In N,N-dimethyl-formamide; at 45 ℃; for 16h;
DOI:10.1016/0008-6215(88)84070-9

Reference yield:

: 121686-52-0
N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

: 121686-58-6
benzyl O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->3)-(4,6-di-O-acetyl-2-O-benzyl-β-D-galactopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutylammonium fluoride / various solvent(s) / 5 h / Ambient temperature

2: 60 percent aq. acetic acid / 4 h / 70 °C

3: 54 percent / 4-toluenesulfonic acid monohydrate / dimethylformamide / Ambient temperature; 1.) 8 h., 2.) 16 h.

4: 89 percent / 1.) 4A molecular sieves, 2.) ethyldiisopropylamine / tetraethylammonium bromide / CH₂Cl₂ / Ambient temperature; 1.) 0.5 h., 2.) 18 h., 3.) 4 d.

5: 69 percent / 60 percent aq. acetic acid / 4 h / 70 °C

6: 75 percent / pyridine / 16 h / Ambient temperature

With pyridine; 4 A molecular sieve; p-toluenesulfonic acid monohydrate; tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine; tetraethylammonium bromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(88)84070-9

Reference yield:

: 121686-52-0
N-{(2S,3R,4R,5S,6R)-2,4-Bis-benzyloxy-5-[(3aS,4R,6S,7R,7aS)-7-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy]-6-benzyloxymethyl-tetrahydro-pyran-3-yl}-acetamide

: 121686-57-5
benzyl O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->3)-(2-O-benzyl-β-D-galactopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutylammonium fluoride / various solvent(s) / 5 h / Ambient temperature

2: 60 percent aq. acetic acid / 4 h / 70 °C

3: 54 percent / 4-toluenesulfonic acid monohydrate / dimethylformamide / Ambient temperature; 1.) 8 h., 2.) 16 h.

4: 89 percent / 1.) 4A molecular sieves, 2.) ethyldiisopropylamine / tetraethylammonium bromide / CH₂Cl₂ / Ambient temperature; 1.) 0.5 h., 2.) 18 h., 3.) 4 d.

5: 69 percent / 60 percent aq. acetic acid / 4 h / 70 °C

With 4 A molecular sieve; p-toluenesulfonic acid monohydrate; tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine; tetraethylammonium bromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(88)84070-9