4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene

Base Information

Chemical Name:4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene
CAS No.:811830-57-6
Molecular Formula:C₂₃H₁₈F₆OS₂
Molecular Weight:488.518
Hs Code.:

Synonyms:4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene

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Chemical Property of 4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene

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Technology Process of 4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene

There total 7 articles about 4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 811830-53-2
1-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-2-(2,4-dimethyl-5-trimethylsilylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

: 811830-57-6
4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.166667h;
DOI:10.1002/chem.200601316

Reference yield:

: 63862-00-0
2,4-dibromo-3,5-dimethylthiophene

: 811830-57-6
4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 78 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane;
DOI:10.1021/ja047169n

Reference yield:

: 591-50-4
iodobenzene

: 811830-57-6
4-[2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: tri-n-butylborate / tetrahydrofuran; hexane / -78 - 20 °C

1.3: 67 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran; hexane / 2 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 97 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: 78 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane; 1.3: Suzuki coupling;
DOI:10.1021/ja047169n