alpha-(Acetyloxy)-N-(phenylmethyl)benzeneacetamide

Base Information

Chemical Name:alpha-(Acetyloxy)-N-(phenylmethyl)benzeneacetamide
CAS No.:81384-43-2
Molecular Formula:C₁₇H₁₇NO₃
Molecular Weight:283.327
Hs Code.:
UNII:0JU4GK6U1I
Nikkaji Number:J2.603.071D

Synonyms:0JU4GK6U1I;UNII-0JU4GK6U1I;81384-43-2;alpha-(Acetyloxy)-N-(phenylmethyl)benzeneacetamide;Benzeneacetamide, alpha-(acetyloxy)-N-(phenylmethyl)-;SCHEMBL4158526;HZUAABDZTNOQFU-UHFFFAOYSA-N;N-benzyl phenyl-alpha-acetoxyacetamide;AKOS024326318;ACETIC ACID BENZYLCARBAMOYL-PHENYL-METHYL ESTER;.ALPHA.-(ACETYLOXY)-N-(PHENYLMETHYL)BENZENEACETAMIDE;BENZENEACETAMIDE, .ALPHA.-(ACETYLOXY)-N-(PHENYLMETHYL)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alpha-(Acetyloxy)-N-(phenylmethyl)benzeneacetamide

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:283.12084340
Heavy Atom Count:21
Complexity:344

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OC(C1=CC=CC=C1)C(=O)NCC2=CC=CC=C2

Technology Process of alpha-(Acetyloxy)-N-(phenylmethyl)benzeneacetamide

There total 5 articles about alpha-(Acetyloxy)-N-(phenylmethyl)benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 4410-32-6
N-benzyl-2-hydroxy-2-phenylacetamide

: 108-24-7
acetic anhydride

: 81384-43-2
2-(benzylamino)-2-oxo-1-phenylethyl acetate

Guidance literature:: With dmap; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1016/S0968-0896(96)00225-8

Reference yield: 55.0%

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 100-52-7
benzaldehyde

: 64-19-7,77671-22-8
acetic acid

: 81384-43-2
2-(benzylamino)-2-oxo-1-phenylethyl acetate

Guidance literature:: at 20 ℃; for 24h;
DOI:10.1080/00397910701863608

Reference yield:

: 100-46-9
benzylamine

: 81384-43-2
2-(benzylamino)-2-oxo-1-phenylethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; laccase from Trametes versicolor; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / aq. phosphate buffer / 24 h / 30 °C / pH 5.2 / Enzymatic reaction

2: dimethyldioctadecylammonium bromide / aq. phosphate buffer / 24 h / pH 5.2 / Green chemistry

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; dimethyldioctadecylammonium bromide; acetic acid; In aq. phosphate buffer; 2: |Passerini Condensation;
DOI:10.1016/j.catcom.2020.106118