2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233246-78-0
Molecular Formula:C₂₆H₁₇F₃N₂O₄
Molecular Weight:478.427
Hs Code.:

Synonyms:2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

Suppliers and Price of 2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

There total 13 articles about 2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374249-83-8
C₂₇H₁₉F₃N₂O₄

: 1233246-78-0
2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 3544-25-0
p-aminophenylacetonitrile

: 1233246-78-0
2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: ethanol / 20 °C

2.1: sodium hexamethyldisilazane / 0 - 20 °C

3.1: oxygen / 20 °C

4.1: methanol; water; sodium hydroxide / 0 - 20 °C

5.1: oxalyl dichloride / chloroform / 20 °C

6.1: tetrahydrofuran; acetonitrile / 20 °C

6.2: 60 °C

7.1: diazomethyl-trimethyl-silane / 20 °C

8.1: trifluoroacetic acid / chloroform / 0 - 20 °C

9.1: pyridine / chloroform / 0 - 20 °C

10.1: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

With pyridine; methanol; oxalyl dichloride; ethanol; water; oxygen; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; acetonitrile; 6.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-35-8
4-tert-butoxycarbonylaminophenylacetonitrile

: 1233246-78-0
2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hexamethyldisilazane / 0 - 20 °C

2.1: oxygen / 20 °C

3.1: methanol; water; sodium hydroxide / 0 - 20 °C

4.1: oxalyl dichloride / chloroform / 20 °C

5.1: tetrahydrofuran; acetonitrile / 20 °C

5.2: 60 °C

6.1: diazomethyl-trimethyl-silane / 20 °C

7.1: trifluoroacetic acid / chloroform / 0 - 20 °C

8.1: pyridine / chloroform / 0 - 20 °C

9.1: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

With pyridine; methanol; oxalyl dichloride; water; oxygen; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; acetonitrile; 5.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009