methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

Base Information

• Chemical Name: methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate
• CAS No.: 265321-23-1
• Molecular Formula: C₁₇H₁₄Br₂FNO₄
• Molecular Weight: 475.109

Synonyms:methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

Chemical Property of methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

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Technology Process of methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

There total 5 articles about methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridinium tribromide + methyl 4-(3-bromo-4-fluorophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate (265321-22-0) → methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate (265321-23-1)

Guidance literature:

With pyridine; In methanol; chloroform;

Reference yield:

methyl 4-(3-bromo-4-fluorophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate (265321-22-0) → methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate (265321-23-1)

Guidance literature:

With pyridine; pyridinium hydrobromide perbromide; In chloroform; for 1h; cooling;

DOI:10.1021/jm030357o

Reference yield:

2H-pyran-3,5(4H,6H)-dione (61363-56-2) → methyl 4-(3-bromo-4-fluorophenyl)-2-(bromomethyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate (265321-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 60 h / 80 °C

2: 0.68 g / pyridinium tribromide; pyridine / CHCl₃ / 1 h / cooling

With pyridine; pyridinium hydrobromide perbromide; In ethanol; chloroform;

DOI:10.1021/jm030357o

upstream raw materials:

methyl 4-(3-bromo-4-fluorophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

2H-pyran-3,5(4H,6H)-dione

methyl (E)-3-aminocrotonate

3-bromo-4-fluorobenzaldehyde

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