(2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile

Base Information

• Chemical Name: (2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile
• CAS No.: 249764-16-7
• Molecular Formula: C₁₇H₂₅N₃O₄
• Molecular Weight: 335.403

Synonyms:(2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile

Chemical Property of (2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile

Chemical Property:

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Technology Process of (2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile

There total 2 articles about (2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

C32H35N3O6 → (2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile (249764-16-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 36.0%

C32H35N3O6 → (2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile (249764-16-7) + (2S,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile (249764-14-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

(2R,3S)-3-Amino-4-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-2-morpholin-4-yl-butyronitrile (249764-16-7) + {2-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-formyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (249764-06-5) → C50H64N4O9Si

Guidance literature:

With sodium sulfate; In dichloromethane; at 20 ℃; for 3h;

Downstream raw materials:

((S)-2-[5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-{[(E)-(1S,2R)-2-cyano-1-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-2-morpholin-4-yl-ethylimino]-methyl}-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Saframycin A

(R)-{(1R,3S)-1-[(S)-1-Amino-2-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-ethyl]-8-hydroxy-5,7-dimethoxy-2,6-dimethyl-1,2,3,4-tetrahydro-isoquinolin-3-yl}-morpholin-4-yl-acetonitrile

{(S)-2-[5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-[(1R,3S)-3-((R)-cyano-morpholin-4-yl-methyl)-8-hydroxy-5,7-dimethoxy-2,6-dimethyl-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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