(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol

Base Information

Chemical Name:(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol
CAS No.:855310-82-6
Molecular Formula:C₃₄H₆₁NO₃Si₂
Molecular Weight:588.034
Hs Code.:

Synonyms:(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol

There total 11 articles about (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855310-81-5
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

: 855310-82-6
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2005.04.019

Reference yield:

: 855310-69-9
C₁₇H₂₁NO₂

: 855310-82-6
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: ytterbium triflate; H₂O / tetrahydrofuran

1.2: BuLi / tetrahydrofuran / Heating

2.1: 73 percent / BF₃*OEt₂ / diethyl ether; acetonitrile / -50 °C

3.1: 97 percent / imidazole / CH₂Cl₂

4.1: DIBALH / tetrahydrofuran

5.1: imidazole / dimethylformamide

6.1: LDA; HMPA / tetrahydrofuran / -78 °C

7.1: DIBALH / toluene / -78 °C

8.1: LiAlH₄ / tetrahydrofuran

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; ytterbium trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Horner-Emmons olefination;
DOI:10.1016/j.tetlet.2005.04.019

Reference yield:

: 855301-94-9
6-phenyl-2,3,5,6,9,10-hexahydro-1H-4-oxa-6a-azacyclopenta[d]naphthalen-3a-ylamine

: 855310-82-6
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: ytterbium triflate; H₂O / tetrahydrofuran / Heating

2.1: ytterbium triflate; H₂O / tetrahydrofuran

2.2: BuLi / tetrahydrofuran / Heating

3.1: 73 percent / BF₃*OEt₂ / diethyl ether; acetonitrile / -50 °C

4.1: 97 percent / imidazole / CH₂Cl₂

5.1: DIBALH / tetrahydrofuran

6.1: imidazole / dimethylformamide

7.1: LDA; HMPA / tetrahydrofuran / -78 °C

8.1: DIBALH / toluene / -78 °C

9.1: LiAlH₄ / tetrahydrofuran

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; ytterbium trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: Horner-Emmons olefination;
DOI:10.1016/j.tetlet.2005.04.019